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KMID : 0363219950330030504
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Korean Journal of Dermatology
1995 Volume.33 No. 3 p.504 ~ p.509
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Therapeutic Effect of Topical Ciclopiroxolamine on Onychomycosis
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이승연
최연상/유희준/손숙자
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Abstract
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Background :
@EN Ciclopiroxolamine solution or cream is the topical antiycotic agent which has been known to have the ability to penetrate the horny skin and nail keratin.
@ES Objectives :
@EN The purpose of this study was to evaluate the therapeutic effect of 1% ciclopiroxolamine solution on onychomycosis.
@ES Methods :
@EN 1% ciclopiroxolamine solution was applied topically to the entire surface of the diseased nail at least twice a day for 12 to 36 weeks according to the severity of nail involvement and degree of improvement in 21 cases of onychomycoses.
@ES Results :
@EN 1. With only topical application of 1% ciclopiroxolamine solution, 14 out of 21 cases(67%) showed 25% or more reduction of the affected nail area, and 8 out 21 cases(38%) showed 50% or more reduction of the affected nail area.
2. There was no significant difference in the degree of improvement according to the duration of disease.
3. Therapeutic effect was relatively high on Candida albicans, while it was relatively low on Aspergillus species.
4. 3 out of 7 cases of mild (up to 30%) involvement showed a 75% or more reduction of the affected nail, while 4 out of 6 cases of severe (60-100%) involvement showed a 25% or less reduction of the affected nail.
5. As side effects during the topical application of 1% ciclopiroxolamine solution, periungual erythema appeared in 3 cases, and a burning sensation in 4 of 21 cases.
@ES Conclusion :
@EN 1% ciclopiroxolamine solution could be tried as an effective therapeutic agent on onychomycosis for the patient who would not be tolerable to oral antifungal medication for associated systemic diseases or who does not want oral medication.
(Kor J Dermatol 1995;33(3) : 504~509)
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